Reduced kidney function and abnormal cardiac structure
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Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2.
A role for myosin phosphorylation in modulating normal cardiac function has long been suspected, and we hypothesized that changing the phosphorylation status of a cardiac myosin light chain might alter cardiac function in the whole animal. To test this directly, transgenic mice were created in which three potentially phosphorylatable serines in the ventricular isoform of the regulatory myosin l...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2012
ISSN: 1759-5061,1759-507X
DOI: 10.1038/nrneph.2012.211